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Quick View

Run -> Run Demo -> View demo results

Click to see video tutorial on Youtube (1 minute)

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Register/Login

Register/Login is optional. If you like to view/download results later, please register and login.

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Input and Run (Run page)

- Condition 1/2: You can compare two conditions (same disease in two different species; two different diseases in same species; case-control comparison in same species ).

- Species: Currently, you can perform analysis in human and mouse.

- Short name of this condition: Give a short name of conditions 1 and 2. These names will appear in charts and results pages.

- TFs and Genes (non-TFs): Gene list, including TFs and non-TFs. A gene per line.

- miRNAs: miRNA list. A miRNA per line.

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Run List (Run List page)

- Run list: If you have input data and run, please select 'run' from this page.

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Results Page

The results pages have nine categories - "Biomolecules", "Interactions", "Motifs", "Hub Nodes", "Targets", "GO", "KEGG Pathway", "Files for CytoScape" and "Tables".

Biomolecules Pages

These pages present miRNAs, TFs and genes provided by users. It is split into two pages:

- Biomolecules: This page presents miRNAs, TFs and genes.

- Common Biomolecules: Common biomolecules between the two conditions.

Interactions Pages

These pages present interactions identified by our server. It is split into two pages:

- Interactions: This page presents miRNA-TF, miRNA-gene, TF-miRNA and TF-gene interactions.

- Common Interactions: Common interactions between the two conditions.

- Summary of Interactions (cnd1): Summary of the integrated regulatory relationships (Condition 1; Table 1).

- Summary of Interactions (cnd2): Summary of the integrated regulatory relationships (Condition 2; Table 3).

Motifs Pages

These pages present three types of motifs identified by our server. It is split into two pages:

- Motifs: This page presents three types of motifs.
Type I: TF-miRNA, miRNA-gene, TF-gene
Type II: miRNA-TF, TF-gene, miRNA-gene
Type III: miRNA-TF, TF-gene, miRNA-gene, TF-miRNA

- Common Motifs: Common motifs between the two conditions.

- Partial Conserved Motifs: Some motifs can be identified in both species, while some can be identified in either species with two interactions exist in both species (indicated with '0').

- Summary of motifs (cnd1) : Summary of 3-node motifs (Condition 1; Table 2).

- Summary of motifs (cnd2): Summary of 3-node motifs (Condition 2; Table 4).

Hub Nodes Pages

Hub nodes and further GO and KEGG pathway analysis:

- Hub Nodes: Hub nodes.

- Targets of Hub (cdn1): Targets of hub nodes (Condition 1).

- Targets of Hub (cdn2): Targets of hub nodes (Condition 2).

- GO of Targets (cdn1): GO enrichment analysis of targets of hub nodes (Condition 1).

- GO of Targets (cdn2): GO enrichment analysis of targets of hub nodes (Condition 2).

- Pathway of Targets (cdn1): KEGG pathway enrichment analysis of targets of hub nodes (Condition 1).

- Pathway of Targets (cdn2): KEGG pathway enrichment analysis of targets of hub nodes (Condition 2).

Files for CytoScape Pages

You can download these files and plot networks using CytoScape:

- Files for CytoScape: These data can feed to CytoScape to plot networks.